Arsenic Poisoning – A Victorian Epidemic

A Victorian Epidemic

In the early 1800s and during the reign of Queen Victoria, murder by arsenic poisoning was epidemic in England.

White arsenic, or arsenic trioxide (As₂O₃), is a metallic oxide that was widely used in the 19th century. It served multiple purposes: as a pesticide to kill vermin and insects, a herbicide, a tonic, a component in medicines, in agriculture as a sheep dip, and even in wallpaper. It was very cheap, odourless, soluble in water, largely tasteless, and freely available up to 1851 (see below).

Symptoms and Misdiagnosis

When ingested with food, arsenic produced symptoms such as vomiting, diarrhoea, and severe stomach cramps, which were often indistinguishable from English cholera and gastroenteritis.

Cholera epidemics were not uncommon during this time, with major outbreaks in:

  • 1831–1832
  • 1848–1849
  • 1853–1854
  • 1866

These outbreaks killed approximately 140,000 people in total.

When taken in small quantities, arsenic is not immediately lethal, but its effects are cumulative, building up in the body over time. In larger doses, it is fatal—though not quickly. Death typically occurred over several hours.

Where death occurred under seemingly normal circumstances, doctors often certified the cause as cholera and did not order an autopsy. Thus, arsenic became the “weapon of choice,” especially among women, who could obtain a sufficient quantity for two old pence (1p) to eliminate unwanted children, husbands, or relatives—and often get away with it.

It is impossible to know how many cases of arsenic poisoning went undetected.


Forensic Breakthroughs in Detection

Early Limitations

Up to 1836, there was no reliable method of detecting arsenic. While earlier test methods were devised by:

  • Carl Scheele (1775)
  • Johann Metzger
  • Valentin Rose
  • Samuel Hahnemann

These were not ideal or sufficiently accurate.

The Marsh Test

In 1836, James Marsh, a chemist at the Royal Arsenal in Woolwich, published a paper detailing a precise methodology for:

  • Detecting traces of arsenic
  • Measuring the actual quantity found

Marsh had worked on the James Boodle case in 1832. Boodle was acquitted due to lack of good forensic evidence, though he later admitted to poisoning his grandfather’s coffee.

The Marsh Test became the standard forensic procedure. It was extremely sensitive, capable of detecting as little as one-fiftieth of a milligram of arsenic. Samples tested included food, drink, stomach contents, and tissue.

The Reinsch Test

In 1841, German chemist Hugo Reinsch introduced a simpler test. His method involved:

  • Using hydrochloric acid solution
  • Depositing metallic arsenic on copper foil

This test could be applied to liquids containing organic matter, making it easier than Marsh’s method in many cases.


Arsenic and the Rise of Female Poisoners

Expertise and Prosecution

As these forensic methods became more widely used, expertise developed in the newly opened teaching hospitals, providing expert witnesses to assist prosecutors. As is often the case, detection became more of a deterrent than punishment, and the number of arsenic poisonings began to decline.

Execution Statistics (1843–1852)

In the decade from 1843 to 1852, 22 women were hanged in England and Wales. 17 of these were arsenic poisoners, several of whom were serial killers.

Executed Women Arsenic Poisoners

Date HangedNameAgePlaceCrime for Which ExecutedOther Probable Victims
10/08/1835Frances Billing & Catherine Frary46 & 40Norwich CastleMurders of Harriet Southgate and Robert Frary—
06/05/1843Betty Eccles38LiverpoolMurder of her stepson WilliamTwo daughters: Alice (10) and Nancy (6)
05/08/1843Sarah Dazley24BedfordMurder of her husbandPrevious husband and her son
13/01/1844Sarah Westwood42StaffordMurder of her husbandNone
02/08/1844Eliza Joyce31Lincoln CastleMurder of her stepson WilliamStepdaughter Emma and daughter Ann
28/12/1844Mary Gallop20ChesterMurder of her fatherNone
11/01/1845Mary Sheming51IpswichMurder of her infant grandsonNone
23/04/1845Sarah Freeman28TauntonMurder of her brother CharlesHusband Henry, son James, and mother Mary
17/04/1847Catherine Foster18Bury St EdmundsMurder of her husband JohnNone
30/07/1847Mary Ann Milner27Lincoln CastleMurder of sister-in-lawConfessed to poisoning three other relatives
14/08/1848Mary May38ChelmsfordMurder of her half-brother William ConstableNone proven
09/08/1849Mary Ball31CoventryMurder of her husbandNone
21/08/1849Mary Ann Geering49LewesMurder of her husbandTwo adult sons
23/08/1849Rebecca Smith44DevizesMurder of her infant sonConfessed to poisoning seven of her children
13/04/1850Mary Reeder20CambridgeMurder of sister Susan LucasNone
25/03/1851Sarah Chesham42ChelmsfordAttempted murder of husbandPossibly two sons and another child
19/08/1851Mary Cage40IpswichMurder of her husbandNone proven
10/04/1852Sarah Ann French27LewesMurder of her husbandNone

Note: Mary Milner hanged herself on the eve of her execution but is included here, as no reprieve was granted and all preparations had been made.

Out of 97 executions in England and Wales during this period, women accounted for 22.6%, the highest proportion ever recorded.


Legal Reform: The Sale of Arsenic Regulation Bill

The growing number of female poisoners—especially Sarah Chesham, dubbed “Sally Arsenic” by the media—finally captured the attention of Parliament.

Introduction of New Regulations

In early 1851, after sustained media pressure, the Earl of Carlisle introduced the Sale of Arsenic Regulation Bill, which proposed the following measures:

  • Suppliers had to keep a register of purchases:
    • Name of the buyer
    • Amount purchased
    • Purpose of use
  • Purchaser had to sign the register
  • Sellers could only sell to known individuals or those accompanied by a witness (who also had to sign)
  • Arsenic had to be coloured for normal-sized purchases to prevent the defense of accidental use
  • Uncoloured (white) arsenic could only be bought in commercial amounts (minimum of 10 lbs)

Legislative Approval

The Bill received House of Lords approval the day before Sarah Chesham was hanged. Although it was originally to include a clause banning women from purchasing arsenic, this was later dropped.


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